Meliksetian | Briggs was founded in 2012 by Anna Meliksetian and Michael Briggs. The program features an intergenerational, international program of artists invited to make focused exhibitions of new or unseen bodies of work . The gallery intends to be a site of discovery, experimentation, cultural and educational exchange, while supporting artists, helping them achieve their ambitions.

The artists in the program investigate various positions, addressing relevant contemporary, philosophical, aesthetic and sociopolitical ideas in their work. These include the dialectic between the production and reception of an artwork, aesthetics and exchange value, ideas of self as performer and selfhood as performance, identity and post-colonialism, cultural theory and appropriation. 

Gallery artists have exhibited frequently in museum and institutional shows, and been featured in major international exhibitions such as the Whitney Biennial, the Venice Biennale, the Saõ Paolo Biennial and the Made in L.A. biennial, and are represented in numerous public collections.