Lyles & King was founded in 2015 in New York's Lower East Side by Isaac Lyles. Recently, gallery artists have been exhibited at La Biennale di Venezia, Venice, and international institutions including Centre Pompidou, FR; British Museum, UK; Hammer Museum, US; Hirshhorn Museum, US; MIT List Visual Arts Center, US; Haus Der Kunst, DE; Nasher Sculpture Center, US; Walker Art Center, US; Swiss Institute, US; SculptureCenter, US; The Aldrich Contemporary Art Museum, US; Brooklyn Museum, US; Museo de Arte Moderno, MX; and many others. Gallery artists are in dozens of museum collections worldwide.

Lyles & King has exhibition spaces at 21 Catherine Street and 19 Henry Street along with an outdoor sculpture and performance space.